Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice

@article{Miyata2009ChlorpheniramineEA,
  title={Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice},
  author={S. Miyata and Shoko Hirano and M. Ohsawa and J. Kamei},
  journal={Psychopharmacology},
  year={2009},
  volume={213},
  pages={441-452}
}
  • S. Miyata, Shoko Hirano, +1 author J. Kamei
  • Published 2009
  • Medicine, Psychology
  • Psychopharmacology
  • RationaleThe traditional antihistamine chlorpheniramine ameliorates panic attacks, phobias, and lowered mood, and this therapeutic effect is independent of the blockade of histamine H1 receptors. Since chlorpheniramine inhibits the reuptake of serotonin (5-HT), the anxiolytic-like effect of chlorpheniramine may be produced by an increase in serotonergic function.ObjectiveTo elucidate the mechanisms underlying the anxiolytic-like effects of chlorpheniramine in mice, we examined the involvement… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 79 REFERENCES
    The tail suspension test: A new method for screening antidepressants in mice
    • 2,564
    Behavioral despair in mice: a primary screening test for antidepressants.
    • 2,946
    Role of 5-HT in stress, anxiety, and depression
    • 859
    The Mouse Brain in Stereotaxic Coordinates
    • 14,130
    • PDF
    Psychopharmacology: The Fourth Generation of Progress
    • 3,069
    Pharmacological profile of antidepressants and related compounds at human monoamine transporters.
    • 760
    • Highly Influential
    Serotoninergic regulation of emotional and behavioural control processes
    • 516
    Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
    • 2,359
    • PDF