Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice

  title={Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice},
  author={S. Miyata and Shoko Hirano and M. Ohsawa and J. Kamei},
  • S. Miyata, Shoko Hirano, +1 author J. Kamei
  • Published 2009
  • Medicine, Psychology
  • Psychopharmacology
  • RationaleThe traditional antihistamine chlorpheniramine ameliorates panic attacks, phobias, and lowered mood, and this therapeutic effect is independent of the blockade of histamine H1 receptors. Since chlorpheniramine inhibits the reuptake of serotonin (5-HT), the anxiolytic-like effect of chlorpheniramine may be produced by an increase in serotonergic function.ObjectiveTo elucidate the mechanisms underlying the anxiolytic-like effects of chlorpheniramine in mice, we examined the involvement… CONTINUE READING


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