Chlorpheniramine and escitalopram: Similar antidepressant and nitric oxide lowering roles in a mouse model of anxiety.

@article{Gammoh2017ChlorpheniramineAE,
  title={Chlorpheniramine and escitalopram: Similar antidepressant and nitric oxide lowering roles in a mouse model of anxiety.},
  author={Omar Salem Gammoh and Fadia Mayyas and Feras W Darwish Elhajji},
  journal={Biomedical reports},
  year={2017},
  volume={6 6},
  pages={675-680}
}
There is a crosstalk between mood disorders and oxidative stress. Chlorpheniramine (CPA), a first generation antihistamine, is hypothesized to have an anxiolytic role at high doses; however, its antidepressant and antioxidant roles have not previously been investigated. The aim of the current study was to evaluate the antidepressant and anxiolytic effects of CPA treatment in association with nitric oxide (NO) and super oxide dismutase (SOD) activity in a mouse model of anxiety. BALB/c mice were… CONTINUE READING
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Response of the nitrergic system to activation of the neuroendocrine stress axis

  • Chen HJC, JG Spiers, C Sernia, NA Lavidis
  • Front Neurosci
  • 2015

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