Chloroquine transport via the malaria parasite's chloroquine resistance transporter.

@article{Martin2009ChloroquineTV,
  title={Chloroquine transport via the malaria parasite's chloroquine resistance transporter.},
  author={Rowena E. Martin and Rosa V Marchetti and Anna I. Cowan and Susan M. Howitt and Stefan Br{\"o}er and Kiaran Kirk},
  journal={Science},
  year={2009},
  volume={325 5948},
  pages={1680-2}
}
The emergence and spread of chloroquine-resistant Plasmodium falciparum malaria parasites has been a disaster for world health. Resistance is conferred by mutations in the Chloroquine Resistance Transporter (PfCRT), an integral membrane protein localized to the parasite's internal digestive vacuole. These mutations result in a marked reduction in the accumulation of chloroquine (CQ) by the parasite. However, the mechanism by which this occurs is unclear. We expressed both wild-type and… CONTINUE READING
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