Chloroquine transport via the malaria parasite's chloroquine resistance transporter.

  title={Chloroquine transport via the malaria parasite's chloroquine resistance transporter.},
  author={Rowena E. Martin and Rosa V Marchetti and Anna I. Cowan and Susan M. Howitt and Stefan Br{\"o}er and Kiaran Kirk},
  volume={325 5948},
The emergence and spread of chloroquine-resistant Plasmodium falciparum malaria parasites has been a disaster for world health. Resistance is conferred by mutations in the Chloroquine Resistance Transporter (PfCRT), an integral membrane protein localized to the parasite's internal digestive vacuole. These mutations result in a marked reduction in the accumulation of chloroquine (CQ) by the parasite. However, the mechanism by which this occurs is unclear. We expressed both wild-type and… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 103 extracted citations


Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…