Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation.

@article{Martinson2010ChloroquineMH,
  title={Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation.},
  author={Jeffrey A. Martinson and Carlos Julio Montoya and Xiomara {\'U}suga and Rollie E. Ronquillo and Alan L. Landay and Seema N. Desai},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 2},
  pages={
          871-81
        }
}
Plasmacytoid dendritic cells (pDC) contribute to antiviral immunity mainly through recognition of microbial products and viruses via intracellular Toll-like receptor 7 (TLR7) or TLR9, resulting in the production of type I interferons (IFNs). Although interferons reduce the viral burden in the acute phase of infection, their role in the chronic phase is unclear. The presence of elevated plasma IFN-alpha levels in advanced HIV disease and its association with microbial translocation in chronic… CONTINUE READING

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