Chloroquine inhibits proinflammatory cytokine release into human whole blood.

  title={Chloroquine inhibits proinflammatory cytokine release into human whole blood.},
  author={Ina Karres and Jason Z Kremer and Ingrid Dietl and Ursula Steckholzer and Marianne Jochum and Wolfgang Ertel},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={274 4},
Excessive synthesis and release of proinflammatory cytokines during endotoxemia causes severe pathophysiological derangements and organ failure. Because the lysosomotropic agent chloroquine has been effective in the treatment of diseases associated with increased secretion of proinflammatory cytokines such as malaria or rheumatoid arthritis, this study evaluates the potential effect of chloroquine on endotoxin-induced cytokinemia using human whole blood from healthy volunteers. Chloroquine… CONTINUE READING


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