Chloroquine-induced nitric oxide increase and cell death is dependent on cellular GSH depletion in A172 human glioblastoma cells.

@article{Park2008ChloroquineinducedNO,
  title={Chloroquine-induced nitric oxide increase and cell death is dependent on cellular GSH depletion in A172 human glioblastoma cells.},
  author={Byung Chul Park and Seung Hee Park and S. Paek and Su-Young Park and Mi-Kyoung Kwak and Han-Gon Choi and Chul Soon Yong and Bong Kyu Yoo and Jung-Ae Kim},
  journal={Toxicology letters},
  year={2008},
  volume={178 1},
  pages={52-60}
}
Chloroquine (CQ) is used to treat malaria and a variety of inflammatory diseases including systemic lupus erythematosus and rheumatoid arthritis. However, CQ is known to cause cytotoxicity of which mechanism is still uncertain. This study investigated the molecular mechanism responsible for the cell death in CQ-treated A172 human glioblastoma cells. CQ-induced apoptotic cell death of the cells in a time- and concentration-dependent manner. CQ also increased the production of nitric oxide in the… CONTINUE READING

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