Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase.

@article{Read1999ChloroquineBI,
  title={Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase.},
  author={Jay A Read and Kay W Wilkinson and Rebecca Tranter and Richard B. Sessions and R. Leo Brady},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 15},
  pages={10213-8}
}
Although the molecular mechanism by which chloroquine exerts its effects on the malarial parasite Plasmodium falciparum remains unclear, the drug has previously been found to interact specifically with the glycolytic enzyme lactate dehydrogenase from the parasite. In this study we have determined the crystal structure of the complex between chloroquine and P. falciparum lactate dehydrogenase. The bound chloroquine is clearly seen within the NADH binding pocket of the enzyme, occupying a… CONTINUE READING

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