Chloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy

  title={Chloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy},
  author={Hye Yun Jeong and Jun Mo Kang and Hak Hoon Jun and Dong-Jin Kim and Seon Hwa Park and Min Ji Sung and J. H. Heo and D. Yang and S. Lee and So-Young Lee},
  journal={Scientific Reports},
  • Hye Yun Jeong, Jun Mo Kang, +7 authors So-Young Lee
  • Published 2018
  • Chemistry, Medicine
  • Scientific Reports
  • We investigated the effects of chloroquine (CQ) and amodiaquine (AQ) on AMPK phosphorylation in renal tubular cells in a diabetic environment in vivo and in vitro. We also examined whether CQ- or AQ-mediated AMPK activity restoration attenuated diabetic tubulopathy by normalizing mitochondrial fragmentation. Human renal proximal epithelial cells (HKC8) were incubated in high-glucose conditions. Diabetes was induced with streptozotocin in male C57/BL6J mice. Treatment with CQ or AQ abolished… CONTINUE READING
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