Chloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy

@article{Jeong2018ChloroquineAA,
  title={Chloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy},
  author={Hye Yun Jeong and Jun Mo Kang and Hak Hoon Jun and Dong-Jin Kim and Seon Hwa Park and Min Ji Sung and J. H. Heo and D. Yang and S. Lee and So-Young Lee},
  journal={Scientific Reports},
  year={2018},
  volume={8}
}
  • Hye Yun Jeong, Jun Mo Kang, +7 authors So-Young Lee
  • Published 2018
  • Chemistry, Medicine
  • Scientific Reports
  • We investigated the effects of chloroquine (CQ) and amodiaquine (AQ) on AMPK phosphorylation in renal tubular cells in a diabetic environment in vivo and in vitro. We also examined whether CQ- or AQ-mediated AMPK activity restoration attenuated diabetic tubulopathy by normalizing mitochondrial fragmentation. Human renal proximal epithelial cells (HKC8) were incubated in high-glucose conditions. Diabetes was induced with streptozotocin in male C57/BL6J mice. Treatment with CQ or AQ abolished… CONTINUE READING
    14 Citations
    Empagliflozin attenuates diabetic tubulopathy by improving mitochondrial fragmentation and autophagy.
    • 16
    • PDF
    [Role of mitochondrial fusion and fission in protective effects of dexmedetomidine against cerebral ischemia/reperfusion injury in mice].
    NR4A1 promotes TNF-α-induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway
    • 4
    • PDF
    Chloroquine cardiac effects and toxicity.A short update.
    • K. Mubagwa
    • Medicine
    • International Journal of Antimicrobial Agents
    • 2020
    • 1
    Mitochondrial Structural Changes in the Pathogenesis of Diabetic Retinopathy
    • 11
    • PDF

    References

    SHOWING 1-10 OF 64 REFERENCES
    PGC1α Activators Mitigate Diabetic Tubulopathy by Improving Mitochondrial Dynamics and Quality Control
    • 17
    • PDF
    Rap1b GTPase ameliorates glucose-induced mitochondrial dysfunction.
    • L. Sun, P. Xie, +7 authors Y. Kanwar
    • Biology, Medicine
    • Journal of the American Society of Nephrology : JASN
    • 2008
    • 58
    • PDF
    Chloroquine increases phosphorylation of AMPK and Akt in myotubes
    • 8
    AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function.
    • 290
    • PDF
    Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models.
    • 495
    • PDF
    Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy.
    • 278
    • PDF