Chloroquine and acid vesicle function.

Abstract

These studies suggest that the site of chloroquine action against the malaria parasite is the acid intracellular vesicle system, and that the critical first step in chloroquine action is to raise parasite vesicle pH. Measurements of acid vesicle buffering capacity and of 3H-chloroquine accumulation suggest that the parasite has a chloroquine-concentrating… (More)

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