Chloroquine Resistant Plasmodium vivax: In Vitro Characterisation and Association with Molecular Polymorphisms

@article{Suwanarusk2007ChloroquineRP,
  title={Chloroquine Resistant Plasmodium vivax: In Vitro Characterisation and Association with Molecular Polymorphisms},
  author={Rossarin Suwanarusk and Bruce D. Russell and Marina Chavchich and Ferryanto Chalfein and Enny Kenangalem and Varakorn Kosaisavee and Budi Prasetyorini and Kim A. Piera and Marion Barends and Alan Brockman and Usa Lek-Uthai and Nicholas M Anstey and Emiliana Tjitra and François Nosten and Qin Cheng and Ric N Price},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={97 - 106}
}
BACKGROUND Treatment failure of chloroquine for P. vivax infections has reached high levels in the eastern provinces of Indonesia, however, in vitro characterization of chloroquine resistance and its associated molecular profile have yet to be determined. METHODS Using a modified schizont maturation assay we investigated the in vitro chloroquine susceptibility profile and molecular polymorphisms of P. vivax isolates collected from Papua, Indonesia, where high levels of clinical chloroquine… CONTINUE READING

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