• Corpus ID: 32118052

Chloropolysporins A, B and C, novel glycopeptide antibiotics from Faenia interjecta sp. nov. V. Comparative studies of the biological properties.

@article{Takatsu1987ChloropolysporinsAB,
  title={Chloropolysporins A, B and C, novel glycopeptide antibiotics from Faenia interjecta sp. nov. V. Comparative studies of the biological properties.},
  author={Toshio Takatsu and T Katayama and Mutsuo Nakajima and S. Takahashi and Tatsuo Haneishi and Teruo Magaribuchi and Masazo Tajima},
  journal={The Journal of antibiotics},
  year={1987},
  volume={40 7},
  pages={
          946-52
        }
}
Chloropolysporins A, B and C, as well as derivatives prepared from this group and alpha- and beta-avoparcins by enzymatic and mild acid hydrolysis, were active against Gram-positive bacteria including clinically isolated methicillin-resistant Staphylococci (MIC 0.39-6.25 micrograms/ml) and anaerobic enterobacteria (MIC 0.10-1.56 micrograms/ml). Derhamnosyl and demannosyl derivatives from both groups of antibiotics showed stronger activities than the parent compounds. The MIC and MBC values… 
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References

SHOWING 1-10 OF 19 REFERENCES
Chloropolysporins A, B and C, novel glycopeptide antibiotics from Faenia interjecta sp. nov. III. Structure elucidation of chloropolysporins.
Structure elucidations of chloropolysporins A, B and C were achieved mainly by chemical degradation studies. These components possessed the same pseudoaglycone in common and their structures were
Chloropolysporins A, B and C, novel glycopeptide antibiotics from Faenia interjecta sp. nov. II. Fermentation, isolation and physico-chemical characterization.
TLDR
Physico-chemical characterizations including molecular formulae revealed that chloropolysporins A, B and C were new members of glycopeptide antibiotics.
Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp.
TLDR
The mechanism of action of teicoplanin is discussed in comparison with those of other inhibitors of cell wall biosynthesis, namely, vancomycin, ristocetin, and gardimycin.
Chloropolysporins A, B and C, novel glycopeptide antibiotics from Faenia interjecta sp. nov. I. Taxonomy of producing organism.
TLDR
Strain SANK 60983, an actinomycete isolated from a soil sample, was found to produce the new glycopeptide antibiotics, chloropolysporins A, B and C and was determined to be a new species of Faenia designatedFaenia interjecta sp.
Chloropolysporins A, B and C, novel glycopeptide antibiotics from Faenia interjecta sp. nov. IV. Partially deglycosylated derivatives.
Chloropolysporins A, B and C, new members of the glycopeptide antibiotic family, were enzymatically and chemically converted to their partially deglycosylated derivatives. The alpha- and
Teicoplanin, antibiotics from Actinoplanes teichomyceticus nov. sp. VI. Chemical degradation: physico-chemical and biological properties of acid hydrolysis products.
TLDR
Quantitative determination of sugars obtained by degradative reactions and NMR/LC-MS studies on suitable derivatives confirmed that all the components carry one N-acyl-D-glucosamine and that at least two of them are characterized by N-decanoyl and N-undecanoysl chains on the D-gl Sucosamine unit.
Specificity of combination between mucopeptide precursors and vancomycin or ristocetin.
  • H. Perkins
  • Biology, Chemistry
    The Biochemical journal
  • 1969
Vancomycin and ristocetin formed complexes on being mixed with mucopeptide precursors from various bacteria, as shown by chromatography, electrophoresis and differential ultraviolet spectra.
MBCs for Staphylococcus aureus as determined by macrodilution and microdilution techniques
TLDR
MBC testing of clindamycin, methicillin, cephalothin, gentamicin, and vancomycin with 67 clinical isolates of Staphylococcus aureus was examined by both standard macrodilution tubes and commercial microdilution trays, finding no significant difference in MBCs was demonstrated by the use of log-phase versus stationary-phase inocula.
The fractional inhibitory concentration (FIC) index as a measure of synergy.
TLDR
The value of the FIC index as a predictor of synergy has been investigated using the antibacterial agents alafosfalin and cephalexin combined together with themselves in fully blind experiments to enhance the credibility of many of the claims of synergy published in the literature.
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