Chloropicrin-induced toxic responses in human lung epithelial cells.

@article{Pesonen2014ChloropicrininducedTR,
  title={Chloropicrin-induced toxic responses in human lung epithelial cells.},
  author={Maija Pesonen and Merja R. H{\"a}kkinen and Kirsi Rilla and Risto O Juvonen and Tapio Kuitunen and Markku J Pasanen and Kirsi H. V{\"a}h{\"a}kangas},
  journal={Toxicology letters},
  year={2014},
  volume={226 2},
  pages={
          236-44
        }
}
Chloropicrin is a slowly evaporating toxic irritant that is known to cause damage in the respiratory system. Here we used a lung epithelial cell line (A549) to study the molecular responses underlying chloropicrin toxicity. Glutathione (GSH), synthetic peptide and 2'-deoxyguanosine were used as in vitro trapping agents to identify early markers of chloropicrin toxicity. Microscopy of the cells revealed massive vacuolization by chloropicrin exposure (80-100μM). The number of apoptotic cells… CONTINUE READING
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