Chlorophyllin suppression of lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells.

@article{Cho2000ChlorophyllinSO,
  title={Chlorophyllin suppression of lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells.},
  author={Kyusung Cho and Seung Hyun Han and Bu Yeon Kim and Sang Gu Hwang and Kwang Kyun Park and Ki Hwa Yang and Alicia S. Chung},
  journal={Toxicology and applied pharmacology},
  year={2000},
  volume={166 2},
  pages={
          120-7
        }
}
Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, functions as an anticarcinogen and antioxidant. In the present study, we investigated the effect of CHL on nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Treatment with CHL inhibited nitric oxide production in the LPS-stimulated RAW 264. 7 cells in a dose-related manner. Competitive RT-PCR analysis, using a DNA competitor as an internal standard, demonstrated that the treatment with 1, 10, and 50… CONTINUE READING
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