Chlorophyll-a analogues conjugated with aminobenzyl-DTPA as potential bifunctional agents for magnetic resonance imaging and photodynamic therapy.

@article{Li2005ChlorophyllaAC,
  title={Chlorophyll-a analogues conjugated with aminobenzyl-DTPA as potential bifunctional agents for magnetic resonance imaging and photodynamic therapy.},
  author={Guolin Li and Adam Slansky and Mahabeer P Dobhal and Lalit N. Goswami and Andrew Graham and Yihui Chen and Peter Kanter and Ronald A. Alberico and J. Spernyak and Janet Morgan and R. Mazurchuk and Allan Oseroff and Zachary Grossman and Ravindra K Pandey},
  journal={Bioconjugate chemistry},
  year={2005},
  volume={16 1},
  pages={32-42}
}
A clinically relevant photosensitizer, 3-devinyl-3-(1-hexyloxyethyl)pyropheophorbide-a (HPPH, a chlorophyll-a derivative), was conjugated with Gd(III)-aminobenzyl-diethylenetriaminepentaacetic acid (DTPA), an experimental magnetic resonance (MR) imaging agent. In vivo reflectance spectroscopy confirmed tumor uptake of HPPH-aminobenzyl-Gd(III)-DTPA conjugate was higher than free HPPH administered intraveneously (iv) to C3H mice with subcutaneously (sc) implanted radiation-induced fibrosarcoma… CONTINUE READING