Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians.

@article{Skjelbo1996ChloroguanideMI,
  title={Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians.},
  author={Erik Skjelbo and Theonest K. Mutabingwa and I B Christian Bygbjerg and Karin Kramer Nielsen and Lars Freng Gram and K Br\oosen},
  journal={Clinical pharmacology and therapeutics},
  year={1996},
  volume={59 3},
  pages={304-11}
}
S-Mephenytoin and chloroguanide (proguanil) oxidation was studied in 216 tanzanians. The mephenytoin S/R ratio in urine ranged from <0.1 to 1.16. The distribution was skewed to the right, without evidence of a bimodal distribution. Ten subjects (4.6%, 2.2% to 8.3%, 95% CI) with an S/R mephenytoin ratio >0.9, were arbitrarily defined as poor metabolizers of mephenytoin. The chloroguanide/cycloguanil ratio ranged from 0.82 to 249. There was a significant correlation between the mephenytoin S/R… CONTINUE READING