Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells.

@article{Bandyopadhyay2004ChlorogenicAI,
  title={Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells.},
  author={Gautam Bandyopadhyay and Tanusree Biswas and K. Roy and S. Mandal and C. Mandal and B. Pal and Samir Bhattacharya and S. Rakshit and D. K. Bhattacharya and U. Chaudhuri and A. Konar and S. Bandyopadhyay},
  journal={Blood},
  year={2004},
  volume={104 8},
  pages={
          2514-22
        }
}
We report that chlorogenic acid (Chl) induces apoptosis of several Bcr-Abl-positive chronic myelogenous leukemia (CML) cell lines and primary cells from CML patients in vitro and destroys Bcr-Abl-positive K562 cells in vivo. In contrast, this compound has no effect on the growth and viability of Bcr-Abl-negative lymphocytic and myeloid cell lines and primary CML cells. Sodium chlorogenate (NaChl) exhibits 2-fold higher efficiency in killing K562 cells compared with Chl. NaChl also induces… Expand
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