Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice.

@article{Cho2010ChlorogenicAE,
  title={Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice.},
  author={Ae-Sim Cho and S M Jeon and Myung-Joo Kim and Jiyoung Yeo and Kwon-Il Seo and Myung-Sook Choi and Mi-Kyung Lee},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2010},
  volume={48 3},
  pages={
          937-43
        }
}
  • Ae-Sim Cho, S. Jeon, +4 authors Mi-Kyung Lee
  • Published 1 March 2010
  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
This study investigated the efficacy of chlorogenic acid on altering body fat in high-fat diet (37% calories from fat) induced-obese mice compared to caffeic acid. Caffeic acid or chlorogenic acid was supplemented with high-fat diet at 0.02% (wt/wt) dose. Both caffeic acid and chlorogenic acid significantly lowered body weight, visceral fat mass and plasma leptin and insulin levels compared to the high-fat control group. They also lowered triglyceride (in plasma, liver and heart) and… 
Chlorogenic acid ameliorates obesity by preventing energy balance shift in high fat diet induced obese mice.
TLDR
Supplementation with chlorogenic acid can improve the high fat induced obesity and associated glucose intolerance mainly via regulating food intake and energy expenditure and modified the gut bacterial composition in a unique way.
Chlorogenic Acid Improves High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice
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Evidence is provided in support of CGA as a potent compound in preventing diet-induced obesity and obesity-related metabolic syndrome and suggests that drinking coffee is beneficial in maintaining metabolic homeostasis when on a high fat diet.
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Chicoric acid prevents obesity by attenuating hepatic steatosis, inflammation and oxidative stress in high-fat diet-fed mice
Abstract Chicoric acid, a natural phenolic acid, has been found to possess multiple biological properties. However, the antiobesity activity of chicoric acid remains unclear. In the present study,
Ameliorating effects of casein glycomacropeptide on obesity induced by high-fat diet in male Sprague-Dawley rats.
  • Shi-ping Xu, X. Mao, Xue Cheng, B. Chen
  • Chemistry, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2013
TLDR
GMP can counteract high-fat diet-induced obesity, which might make it a potential ingredient with anti-obesity activity, and reduce lipid accumulation and enhance antioxidant capability of obese rats.
Chlorogenic acid attenuates high-carbohydrate, high-fat diet-induced cardiovascular, liver, and metabolic changes in rats.
TLDR
Chlorogenic acid decreased inflammation and fat deposition in the liver along with reduced plasma liver enzyme activities of obese rats but did not change the plasma lipid profile, and increased diversity of gut microbiota, which may improve overall metabolism in the body.
Supplementation of a high-fat diet with chlorogenic acid is associated with insulin resistance and hepatic lipid accumulation in mice.
TLDR
It is suggested that CGA supplementation in a high-fat diet does not protect against features of the metabolic syndrome in diet-induced obese mice.
Haw pectin pentaglaracturonide inhibits fatty acid synthesis and improves insulin sensitivity in high-fat-fed mice
Abstract Haw pectin pentaglaracturonide (HPPS) significantly lowered the liver weights, hepatic triglycerides (TG) and total lipid levels of high-fat fed mice compared to those of high-fat control
Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice
TLDR
OLE prevents obesity development by regulating the expression of molecules involved in adipogenesis and thermogenesis, which significantly suppressed weight gain, food efficiency ratio, visceral fat accumulation, and serum lipid composition in HFD-induced mice.
5-Caffeoylquinic acid decreases diet-induced obesity in rats by modulating PPARα and LXRα transcription.
TLDR
5-CQA may improve lipid metabolism disorders by altering the expression of PPARα and LXRα, which are involved in multiple intracellular signalling pathways, and this effect significantly ameliorated this effect.
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