Chlorogenic acid attenuates high mobility group box 1 (HMGB1) and enhances host defense mechanisms in murine sepsis.

@article{Lee2013ChlorogenicAA,
  title={Chlorogenic acid attenuates high mobility group box 1 (HMGB1) and enhances host defense mechanisms in murine sepsis.},
  author={Chan-Ho Lee and Seong-Jin Yoon and Sun-Mee Lee},
  journal={Molecular medicine},
  year={2013},
  volume={18},
  pages={
          1437-48
        }
}
Sepsis is a complex, multifactorial, rapidly progressive disease characterized by an overwhelming activation of the immune system and the countervailing antiinflammatory response. In the current study in murine peritoneal macrophages, chlorogenic acid suppressed endotoxin-induced high mobility group box 1 (HMGB1) release in a concentration-dependent manner. Administration of chlorogenic acid also attenuated systemic HMGB1 accumulation in vivo and prevented mortality induced by endotoxemia and… CONTINUE READING
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