Chloroform inhibits the development of diethylnitrosamine-initiated, phenobarbital-promoted gamma-glutamyltranspeptidase and placental form glutathione S-transferase-positive foci in rat liver.

@article{Reddy1992ChloroformIT,
  title={Chloroform inhibits the development of diethylnitrosamine-initiated, phenobarbital-promoted gamma-glutamyltranspeptidase and placental form glutathione S-transferase-positive foci in rat liver.},
  author={T. Reddy and F. Daniel and E. Lin and J. Stober and G. Olson},
  journal={Carcinogenesis},
  year={1992},
  volume={13 8},
  pages={
          1325-30
        }
}
In this study we demonstrate that chloroform, a widely used industrial solvent, a medicinal chemical and a common drinking water contaminant, reduces the number of detectable preneoplastic enzyme-altered foci [gamma-glutamyltranspeptidase-positive (GGT+) and placental form glutathione S-transferase-positive (GST-P+)] in the liver of male Fischer 344 rats. The animals were given a partial hepatectomy and 18 h later received a single oral dose of either 0.5 mmol/kg diethylnitrosamine (DENA) or… Expand
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Mixtures of these seven chemicals did not appear to act as promoters of hepatic foci at environmentally relevant concentrations, and some mixture combinations appeared to decrease promotional activity. Expand
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PPARgamma ligands are potential chemopreventive agents for liver carcinogenesis and reduction of rGST P-positive foci by diethylnitrosamine and induction of liver cancers was markedly suppressed by a continuous feeding of Pio at 200 ppm. Expand
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Since the previous version of this chapter [1], there have been numerous studies on chloroform (CHC~:J (CAS No. 67-66-3)) in order to explain the mechanism of its action. CHCl3 had detrimental orExpand
Chloroform in drinking water prevents hepatic cell proliferation induced by chloroform administered by gavage in corn oil to mice.
  • M. A. Pereira, M. Grothaus
  • Medicine, Chemistry
  • Fundamental and applied toxicology : official journal of the Society of Toxicology
  • 1997
TLDR
Exposure to chloroform in drinking water reduced both the hepatotoxicity and the enhanced cell proliferation elicited in response tochloroform administered by gavage in corn oil, suggesting that it would also reduce the hepatocarcinogenic activity of chloroformed by g Savage. Expand
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No association was found between detailed estimates of lifetime total THM exposure and colorectal cancer in the large case–control study population, and negative associations with chloroform concentrations and ingestion suggest differences among specific THMs, but these findings should be confirmed in other study populations. Expand
[Pexoxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats].
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Concise International Chemical Assessment Document 68
CHLOROFORM Please note that the layout and pagination of this pdf file are not identical to the version in press First draft prepared
Toxicological profile for Chloroform.