Chloroform extract of deer antler inhibits osteoclast differentiation and bone resorption.

@article{Li2007ChloroformEO,
  title={Chloroform extract of deer antler inhibits osteoclast differentiation and bone resorption.},
  author={Yin-ji Li and Tae-Hee Kim and Han Bok Kwak and Zang Hee Lee and Soo-Young Lee and Gil-ja Jhon},
  journal={Journal of ethnopharmacology},
  year={2007},
  volume={113 2},
  pages={191-8}
}
It has been reported that deer antler extract has anti-bone resorptive activity in vivo. However, little is known about the cellular and molecular mechanism of this effect. In this study, we investigated the effects of deer antler extracts on osteoclast differentiation and bone-resorption in vitro. Chloroform extract (CE-C) of deer antler inhibited osteoclast differentiation in mouse bone marrow cultures stimulated by receptor activator of NF-kappaB ligand (RANKL) and macrophage-colony… CONTINUE READING

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