Chlorodifluoromethane-triggered formation of difluoromethylated arenes catalysed by palladium.

Abstract

Difluoromethylated aromatic compounds are of increasing importance in pharmaceuticals, agrochemicals and materials. Chlorodifluoromethane (ClCF2H), an inexpensive, abundant and widely used industrial raw material, represents the ideal and most straightforward difluoromethylating reagent, but introduction of the difluoromethyl group (CF2H) from ClCF2H into… (More)
DOI: 10.1038/nchem.2746

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