Chlorobenzylidine-calf thymus DNA interaction II: circular dichroism and nuclear magnetic resonance studies.

@article{Zhong2004ChlorobenzylidinecalfTD,
  title={Chlorobenzylidine-calf thymus DNA interaction II: circular dichroism and nuclear magnetic resonance studies.},
  author={Wen-ying Zhong and J Yu and Yingqiu Liang and Keqiang Fan and Luhua Lai},
  journal={Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy},
  year={2004},
  volume={60 13},
  pages={2985-92}
}
The binding of chlorobenzylidine to calf thymus DNA has been studied in detail by means of circular dichroism (CD), nuclear magnetic resonance (1H NMR), viscosimetry and denaturation temperature (Tm). Chlorobenzylidine is found to intercalate between base pairs of DNA as evidence by: (1) induced circular dichroism; (2) broadened 1H NMR signals; (3) enhanced viscosity; and (4) increased denaturation temperature of the DNA helix. In addition, Scatchard plot from CD titration data gives a binding… CONTINUE READING

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