Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy.

  title={Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy.},
  author={Andreas Benesic and Gerald Schwerdt and Ruth Freudinger and Sigrid Mildenberger and Franziska Groezinger and Brigitte Wollny and Antje Kirchhoff and Michael Gekle},
  journal={Kidney & blood pressure research},
  volume={29 5},
Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO. Depletion of sulfhydryl (SH) groups has been reported from cell culture, animal and clinical studies. In this work the effect of CAA on human proximal tubule cells in primary culture (hRPTEC) was investigated. Toxicity of CAA was determined by protein content, cell number, LDH release, trypan blue exclusion assay and caspase-3… CONTINUE READING


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