Chlornaphazine and chlorambucil induce dominant lethal mutations in male mice.

@article{Barnett2003ChlornaphazineAC,
  title={Chlornaphazine and chlorambucil induce dominant lethal mutations in male mice.},
  author={Lois B Barnett and Susan E. Lewis},
  journal={Mutation research},
  year={2003},
  volume={543 2},
  pages={145-54}
}
Two antineoplastic agents, chlornaphazine (CN) and chlorambucil (CHL), were tested for the induction of dominant lethal mutations in male mice. Both compounds are nitrogen mustard derivatives and have been shown to be genotoxic in a variety of organisms. CN was administered intraperitoneally to DBA/2J male mice at a dosage of 0, 500, 1000, or 1500 mg/kg body weight (bw). Immediately following treatment, each male was mated at 4-day intervals to two virgin C57BL/6J females. CHL was administered… CONTINUE READING