Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol-fed rats.

@article{Liu2002ChlormethiazoleTP,
  title={Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol-fed rats.},
  author={C. Liu and J. Chung and H. Seitz and R. Russell and X. Wang},
  journal={Alcoholism, clinical and experimental research},
  year={2002},
  volume={26 11},
  pages={
          1703-9
        }
}
  • C. Liu, J. Chung, +2 authors X. Wang
  • Published 2002
  • Medicine, Psychology
  • Alcoholism, clinical and experimental research
  • BACKGROUND Chronic ethanol intake results in decreased hepatic vitamin A levels through both enhanced degradation of vitamin A via a cytochrome P450 enzyme (CYP)-dependent process and increased mobilization of vitamin A from the liver into the circulation. This study investigated whether treatment with chlormethiazole, a CYP inhibitor, restores vitamin A in the livers of ethanol-fed rats. METHODS Ethanol-exposed and non-ethanol-exposed rats were treated with or without chlormethiazole (10 and… CONTINUE READING
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