Chlorine-induced injury to the airways in mice.

  title={Chlorine-induced injury to the airways in mice.},
  author={James Martin and Holly R Campbell and Hiroaki Iijima and Denyse Gautrin and J P Malo and David H. Eidelman and Qutayba A Hamid and Karim Maghni},
  journal={American journal of respiratory and critical care medicine},
  volume={168 5},
Exposure to chlorine gas (Cl2) causes occupational asthma that we hypothesized occurs through the induction of airway inflammation and airway hyperresponsiveness by oxidative damage. Respiratory mechanics and airway responsiveness to methacholine were assessed in A/J mice 24 hours after a 5-minute exposure to 100, 200, 400, or 800 ppm Cl2 and 2 and 7 days after inhalation of 400 ppm Cl2. Airway responsiveness was higher 24 hours after 400 and 800 ppm Cl2. Responsiveness after inhalation of 400… CONTINUE READING


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