Chlorine Dioxide Gas Inactivation of Beta - Lactams

  • Kevin Lorcheim
  • Published 2012


Allergic reactions to beta-lactams, such as penicillin, can be life-threatening. Due to the large number of individuals allergic to beta-lactams, a method for their inactivation was explored such that a contaminated area could be treated and re-used. The goal was to validate a cycle that could be used to treat a pharmaceutical manufacturer’s beta-lactam manufacturing equipment for the future production of non-beta-lactam compounds. Testing was conducted using chlorine dioxide gas at various concentrations and exposure times in an effort to achieve the pharmaceutical manufacturer’s required 3-log (99.9%) reduction of eight different beta-lactams on various surfaces. After a period of cycle development, multiple chlorine dioxide gas cycles at various concentrations and exposure lengths were shown effective in inactivating the eight beta-lactam compounds to a successful degree.

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Cite this paper

@inproceedings{Lorcheim2012ChlorineDG, title={Chlorine Dioxide Gas Inactivation of Beta - Lactams}, author={Kevin Lorcheim}, year={2012} }