Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation.

@article{Weiss1982ChlorinationOT,
  title={Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation.},
  author={Stephen J Weiss and Rudiger Klein and A. S. Slivka and Min Wei},
  journal={The Journal of clinical investigation},
  year={1982},
  volume={70 3},
  pages={598-607}
}
The model hydrogen peroxide-myeloperoxidase-chloride system is capable of generating the powerful oxidant hypochlorous acid, which can be quantitated by trapping the generated species with the beta-amino acid, taurine. The resultant stable product, taurine chloramine, can be quantitated by its ability to oxidize the sulfhydryl compound, 5-thio-2-nitro-benzoic acid to the disulfide, 5,5'-dithiobis(2-nitroben-zoic acid) or to oxidize iodide to iodine. Using this system, purified myeloperoxidase… CONTINUE READING
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