Chlorination Inhibitors in Streptomyces aureofaciens

Abstract

IN a Belgian patent1 granted to Spofa (Czechoslovakia) a number of pyrimidines chlorinated in the 2 position were reported to be active in inhibiting halogenation in the biosynthesis of chlortetracycline resulting instead in the production of high concentrations of tetracycline. It was of interest to us to test such compounds in the Streptomyces… (More)
DOI: 10.1038/219291a0

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