Chlorides, Potassium and Experimental Cardiac Necroses

@article{Prioreschi1963ChloridesPA,
  title={Chlorides, Potassium and Experimental Cardiac Necroses},
  author={P. Prioreschi},
  journal={Circulation Research},
  year={1963},
  volume={12},
  pages={55–57}
}
It is known that the cardiac necroses produced by 9α-fluorocortisol (F-COL) plus Na2HPO4 are prevented by the administration of chlorides or potassium salts. In this paper it is shown that various chlorides not only significantly correct the depletion of myocardial potassium elicited by F-COL + Na2HPO4 but increase the potassium concentration in the heart of normal animals. In view of these facts and of earlier experiments that have shown that F-COL alone diminishes cardiac potassium without… Expand
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References

SHOWING 1-6 OF 6 REFERENCES
Role of Potassium in the Pathogenesis of the “Electrolyte‐Steroid‐Cardiopathy with Necrosis”
TLDR
The author concludes that, although it is conceivable that the diminution of potassium in the heart could favor the development of the necroses, the hypothesis of the ESCN as a result of a simple potassium depletion cannot be accepted. Expand
Effect of various electrolytes upon cardiac and skeletal musculature.
  • H. Selye, E. Bajusz
  • Chemistry, Medicine
  • British journal of pharmacology and chemotherapy
  • 1959
TLDR
Equimolecular amounts of sodium given in the form of sodium chloride did not cause cardiac necroses or muscular cramps in rats maintained on the potassium-deficient diet and the anion must play a decisive rôle, since equivalent amounts of NaCl are ineffective. Expand
The Chemical Prevention of Cardiac Necroses
  • M. Goodkind
  • Computer Science
  • The Yale Journal of Biology and Medicine
  • 1959
TLDR
This book is a lucid, rigorous, and stimulating prototype of the manner in which such controversial and inaccessible subjects should be handled. Expand
The Pluricausal Cardiopathios
  • Circulation Research, Volume XII,
  • 1961
The Pluricausal Cardiopathios. Springfield
  • 1961
An experimental type of muscular dystrophy and role of chlorides in its prevention
  • Oanad. Fed. Biol. Soc, Second Annual Meeting,
  • 1959