Chloride transport in functionally active phagosomes isolated from Human neutrophils.

@article{Aiken2012ChlorideTI,
  title={Chloride transport in functionally active phagosomes isolated from Human neutrophils.},
  author={Martha L. Aiken and Richard G. Painter and Yun Zhou and Guoshun Wang},
  journal={Free radical biology & medicine},
  year={2012},
  volume={53 12},
  pages={
          2308-17
        }
}
Chloride anion is critical for hypochlorous acid (HOCl) production and microbial killing in neutrophil phagosomes. However, the molecular mechanism by which this anion is transported to the organelle is poorly understood. In this report, membrane-enclosed and functionally active phagosomes were isolated from human neutrophils by using opsonized paramagnetic latex microspheres and a rapid magnetic separation method. The phagosomes recovered were highly enriched for specific protein markers… CONTINUE READING
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