Chloride removal and excitation-contraction coupling in guinea pig ileal smooth muscle.

@article{Rangachari1986ChlorideRA,
  title={Chloride removal and excitation-contraction coupling in guinea pig ileal smooth muscle.},
  author={Patangi K Rangachari and Christopher R. Triggle},
  journal={Canadian journal of physiology and pharmacology},
  year={1986},
  volume={64 12},
  pages={1521-7}
}
The effect of extracellular Cl (Cl-o) removal on contractions evoked by a selective muscarinic agonist, cis-2-methyl-4-dimethylaminomethyl 1,3-dioxolane methiodide (CD), and high K+ depolarizations in the isolated guinea pig ileal longitudinal muscle was studied. The replacement of Cl-o with impermeant anions, such as isethionate (Ise-), was found to selectively inhibit a portion of the initial phasic response to K+ and CD, leaving the secondary and sustained tonic responses unchanged. In Ca2… CONTINUE READING

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