Chloride movements in human neutrophils. Diffusion, exchange, and active transport

  title={Chloride movements in human neutrophils. Diffusion, exchange, and active transport},
  author={Louis Simchowitz and Paul De Weer},
  journal={The Journal of General Physiology},
  pages={167 - 194}
Chloride content and fluxes were measured in isolated resting human peripheral polymorphonuclear leukocytes. The intracellular Cl concentration of cells kept at 37 degrees C in 148 mM Cl media was approximately 80 meq/liter cell water, fourfold higher than expected for passive distribution at the cell's estimated membrane potential (approximately -53 mV). All intracellular Cl was rapidly exchangeable with external 36Cl. Cells lost Cl exponentially into Cl-free media, and reaccumulated it when… CONTINUE READING


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