Chloride modulation of insulin release, 86Rb+ efflux, and 45Ca2+ fluxes in rat islets stimulated by various secretagogues.

@article{Tamagawa1983ChlorideMO,
  title={Chloride modulation of insulin release, 86Rb+ efflux, and 45Ca2+ fluxes in rat islets stimulated by various secretagogues.},
  author={Tomoharu Tamagawa and Jean-Claude Henquin},
  journal={Diabetes},
  year={1983},
  volume={32 5},
  pages={416-23}
}
Substitution of extracellular Cl- by impermeant isethionate (5 mM residual Cl-) caused a monophasic inhibition of glucose-stimulated insulin release, accompanied by an initial transient increase and a secondary lasting decrease in 86Rb+ efflux from perifused islets. Cl- reintroduction restored insulin release with an overshoot above control values and… CONTINUE READING