Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents.

@article{Moroni2011ChlorideII,
  title={Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents.},
  author={Mirko Moroni and Istv{\'a}n B{\'i}r{\'o} and Michele Giugliano and Ranjit Vijayan and Philip C. Biggin and Marco Beato and Lucia G Sivilotti},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 40},
  pages={14095-106}
}
In the vertebrate CNS, fast synaptic inhibition is mediated by GABA and glycine receptors. We recently reported that the time course of these synaptic currents is slower when intracellular chloride is high. Here we extend these findings to measure the effects of both extracellular and intracellular chloride on the deactivation of glycine and GABA currents at both negative and positive holding potentials. Currents were elicited by fast agonist application to outside-out patches from HEK-293… CONTINUE READING
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