Chloride influx aggravates Ca2+-dependent AMPA receptor-mediated motoneuron death.

@article{Damme2003ChlorideIA,
  title={Chloride influx aggravates Ca2+-dependent AMPA receptor-mediated motoneuron death.},
  author={Phillip Van Damme and Geert Callewaert and Jan Eggermont and Wim Robberecht and Ludo Van Den Bosch},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 12},
  pages={4942-50}
}
AMPA receptor-mediated excitotoxicity has been implicated in the pathogenesis of stroke, neurotrauma, epilepsy, and many neurodegenerative diseases such as motoneuron disease. We studied the role of Cl- in AMPA receptor-mediated Ca2+-dependent excitotoxicity in cultured rat spinal motoneurons. Using the gramicidin perforated patch-clamp technique, the… CONTINUE READING