Chloride channels of high conductance in the microvillous membrane of term human placenta.

@article{Brown1993ChlorideCO,
  title={Chloride channels of high conductance in the microvillous membrane of term human placenta.},
  author={Peter de Nully Brown and Susan L. Greenwood and James Robinson and Robert D H Boyd},
  journal={Placenta},
  year={1993},
  volume={14 1},
  pages={103-15}
}
The patch clamp technique has been used to study ion channels in the undisturbed microvillous membrane of the human placental syncytiotrophoblast. In villi from 55 placentae delivered by caesarean section, high resistance seals were achieved in approximately 30 percent of attempts. Of these, a large conductance chloride channel was identified in seven inside-out and two 'cell' attached patches. The channel had the following properties: (a) a slope conductance of 313 +/- 9 pS, (b) the presence… CONTINUE READING

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