Chloride channels in the loop of Henle.

  title={Chloride channels in the loop of Henle.},
  author={W. Brian Reeves and Christopher J. Winters and Thomas E. Andreoli},
  journal={Annual review of physiology},
Cl- transport in the loop of Henle is responsible for reclamation of 25-40% of the filtered NaCl load and for the formation of dilute urine. Our understanding of the physiologic and molecular mechanisms responsible for Cl- reabsorption in both the thin ascending limb and thick ascending limb of Henle's loop has increased greatly over the last decade. Plasma membrane Cl- channels are known to play an integral role in transcellular Cl- transport in both the thin and thick ascending limbs. This… CONTINUE READING

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