Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets.

@article{Peretti2015ChlorideCI,
  title={Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets.},
  author={Marta Peretti and Marina Angelini and Nicoletta Savalli and Tullio Florio and Stuart H. Yuspa and Michele Mazzanti},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1848 10 Pt B},
  pages={2523-31}
}
In recent decades, growing scientific evidence supports the role of ion channels in the development of different cancers. Both potassium selective pores and chloride permeabilities are considered the most active channels during tumorigenesis. High rate of proliferation, active migration, and invasiveness into non-neoplastic tissues are specific properties of neoplastic transformation. All these actions require partial or total involvement of chloride channel activity. In this context, this… CONTINUE READING

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