Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity

Abstract

Platelets enhance thrombin generation at sites of vascular injury by exposing phosphatidylserine during necrosis-like cell death. Anoctamin 6 (Ano6) is required for Ca2+-dependent phosphatidylserine exposure and is defective in patients with Scott syndrome, a rare bleeding disorder. Ano6 may also form Cl− channels, though the role of Cl− fluxes in platelet… (More)
DOI: 10.1038/cddis.2013.495

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