Chloride channels and endocytosis: new insights from Dent's disease and CLC-5 knockout mice.

@article{Devuyst2004ChlorideCA,
  title={Chloride channels and endocytosis: new insights from Dent's disease and CLC-5 knockout mice.},
  author={Olivier Devuyst},
  journal={Bulletin et memoires de l'Academie royale de medecine de Belgique},
  year={2004},
  volume={159 Pt 2},
  pages={212-7}
}
  • Olivier Devuyst
  • Published 2004 in
    Bulletin et memoires de l'Academie royale de…
Dent's disease is an hereditary renal tubular disorder characterized by low-molecular-weight (LMW) proteinuria, hypercalciuria and nephrolithiasis. The disease is due to mutations of CLC-5, a member of the family of voltage-gated CLC chloride channels. CLC-5 is distributed in cells lining the proximal tubule (PT) of the kidney, where it co-localizes with albumin-containing endocytic vesicles that form part of the receptor-mediated endocytic pathway that mediates the reabsorption of low… CONTINUE READING
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