Chloride channel blockers activate an endogenous cationic current in oocytes of Bufo arenarum

A two-electrode, voltage-clamp technique was used to measure the effect of the Cl− channel blockers, 9-anthracene carboxylic acid and niflumic acid, upon the ionic currents of oocytes of the South American toad Bufo arenarum. The main results were: (1) both blockers produced a reversible increase of the outward currents on a dose-dependent manner; (2) the… CONTINUE READING