Chloride binding site of neurotransmitter sodium symporters.

  title={Chloride binding site of neurotransmitter sodium symporters.},
  author={Adriana K Kantcheva and Matthias Quick and Lei Shi and Anne-Marie Lund Winther and Sebastian Stolzenberg and Harel Weinstein and Jonathan A. Javitch and Poul Nissen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 21},
Neurotransmitter:sodium symporters (NSSs) play a critical role in signaling by reuptake of neurotransmitters. Eukaryotic NSSs are chloride-dependent, whereas prokaryotic NSS homologs like LeuT are chloride-independent but contain an acidic residue (Glu290 in LeuT) at a site where eukaryotic NSSs have a serine. The LeuT-E290S mutant displays chloride… CONTINUE READING