Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5

@article{Picollo2005ChlorideprotonAA,
  title={Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5},
  author={Alessandra Picollo and Michael Pusch},
  journal={Nature},
  year={2005},
  volume={436},
  pages={420-423}
}
ClC-4 and ClC-5 are members of the CLC gene family, with ClC-5 mutated in Dent's disease, a nephropathy associated with low-molecular-mass proteinuria and eventual renal failure. ClC-5 has been proposed to be an electrically shunting Cl- channel in early endosomes, facilitating intraluminal acidification. Motivated by the discovery that certain bacterial… CONTINUE READING