Chlorhexidine release from poly(ε-caprolactone) films prepared by solvent evaporation

@inproceedings{Medlicott1996ChlorhexidineRF,
  title={Chlorhexidine release from poly(ε-caprolactone) films prepared by solvent evaporation},
  author={Natalie J. Medlicott and Ian G Tucker and Michael John Rathbone and Doug W. Holborow and David S. Jones},
  year={1996}
}
Abstract The effect of selected formulation variables on the release of chlorhexidine from poly(e-caprolactone) films was evaluated in vitro using a complete factorial experimental design. Repeated measures analysis of variance showed chlorhexidine type (diacetate or base), drug load (10, 20 or 30% w/w), chlorhexidine particle size ( or 63−125 μm ) and film side (upper or lower) significantly affected the percentage released over 10 and 30 days. Significant interactions were also observed… CONTINUE READING

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