Chlorhexidine prophylaxis for chemotherapy- and radiotherapy-induced stomatitis: a randomized double-blind trial.

@article{Ferretti1990ChlorhexidinePF,
  title={Chlorhexidine prophylaxis for chemotherapy- and radiotherapy-induced stomatitis: a randomized double-blind trial.},
  author={Gerald A. Ferretti and Ted P Raybould and A. T. Brown and John S. Macdonald and Mike Greenwood and Yosh Maruyama and John D Geil and Thomas T Lillich and Robert C. Ash},
  journal={Oral surgery, oral medicine, and oral pathology},
  year={1990},
  volume={69 3},
  pages={331-8}
}
Patients receiving cytotoxic antineoplastic therapy often have treatment-associated stomatitis. A 0.12% chlorhexidine digluconate mouthrinse was evaluated (15 ml, three times a day) in a prospective, double-blind randomized trial as prophylaxis against cytotoxic therapy-induced damage to oral soft tissues. Seventy subjects, forty inpatients receiving high-dose chemotherapy and thirty outpatients receiving high-dose head and neck radiation therapy, were evaluated. Chlorhexidine mouthrinse… CONTINUE READING

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Efficacy of chlorhexidine for the prevention and treatment of oral mucositis in cancer patients: a systematic review with meta-analyses.

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