Chlorhexidine-induced apoptosis or necrosis in L929 fibroblasts: A role for endoplasmic reticulum stress.

@article{Faria2009ChlorhexidineinducedAO,
  title={Chlorhexidine-induced apoptosis or necrosis in L929 fibroblasts: A role for endoplasmic reticulum stress.},
  author={Gisele Faria and Cristina Ribeiro de Barros Cardoso and Roy Edward Larson and Jo{\~a}o S. Silva and Marcos Ant{\^o}nio Rossi},
  journal={Toxicology and applied pharmacology},
  year={2009},
  volume={234 2},
  pages={256-65}
}
Chlorhexidine (CHX), widely used as antiseptic and therapeutic agent in medicine and dentistry, has a toxic effect both in vivo and in vitro. The intrinsic mechanism underlying CHX-induced cytotoxicity in eukaryotic cells is, however, still unknown. A recent study from our laboratory has suggested that CHX may induce death in cultured L929 fibroblasts via endoplasmic reticulum (ER) stress. This hypothesis was further tested by means of light and electron microscopy, quantification of apoptosis… CONTINUE READING

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