Chlorhexidine Hypersensitivity : A Critical and Updated Review

  title={Chlorhexidine Hypersensitivity : A Critical and Updated Review},
  author={Di Leo and Trautmann and Nettis and Ferrannini},
  • Di Leo, Trautmann, +1 author Ferrannini
  • Published 2013
Chlorhexidine (1:6-di[4-chlorophenyldiguanido]-hexane) (CHL) is a synthetic topical disinfectant industrially produced since 1954. It is a chlorophenyl-bis-biguanide containing two chloroguanide chains linked by a hexamethylene chain (Figure 1). It is a strong base, and at physiological pH a dication. It is usually insoluble in water so it needs to be formulated with either gluconic or acetic acid to form watersoluble digluconate or diacetate salts. CHL solutions are colourless and odourless… CONTINUE READING
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