Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis.

@article{Darouiche2010ChlorhexidineAlcoholVP,
  title={Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis.},
  author={Rabih O. Darouiche and Matthew J. Wall and Kamal M. F. Itani and Mary F. Otterson and Alexandra Louise Webb and Matthew Moore Carrick and Harold J. Miller and Samir S. Awad and Cynthia T Crosby and Michael C. Mosier and Atef Alsharif and David H. Berger},
  journal={The New England journal of medicine},
  year={2010},
  volume={362 1},
  pages={
          18-26
        }
}
BACKGROUND Since the patient's skin is a major source of pathogens that cause surgical-site infection, optimization of preoperative skin antisepsis may decrease postoperative infections. We hypothesized that preoperative skin cleansing with chlorhexidine-alcohol is more protective against infection than is povidone-iodine. METHODS We randomly assigned adults undergoing clean-contaminated surgery in six hospitals to preoperative skin preparation with either chlorhexidine-alcohol scrub or… 
View on PubMed
academicdepartments.musc.edu
953 Citations
Highly Influential Citations
17
Background Citations
108
Methods Citations
31
Results Citations
12

953 Citations

Citation Type

Citation Type

Chlorhexidine Gluconate vs Povidone-Iodine in the Prevention of Clean-Contaminated Surgical Site Infections
TLDR
It is found that the application of 2% CG reduced the incidence of SSIs by 41% compared to 10% PI, and this study demonstrated statistical significance (p = 0.0049).
Chlorhexidine–alcohol versus povidone–iodine as preoperative skin antisepsis for prevention of surgical site infection in cesarean delivery—a pilot randomized control trial
TLDR
The study found that the patients who received chlorhexidine–alcohol as skin antiseptic had less chance of developing SSI than those who received povidone–iodine; however, it did not reach a statistical significance.
Chlorhexidine-Alcohol Compared With Povidone-Iodine for Preoperative Topical Antisepsis for Abdominal Hysterectomy.
TLDR
In abdominal hysterectomy performed for benign indications, chlorhexidine-alcohol-based skin antisepsis is associated with overall lower odds of surgical site infection compared with povidone-iodine.
Comparison of the efficacy of chlorhexidine gluconate versus povidone iodine as preoperative skin preparation for the prevention of surgical site infections in clean-contaminated upper abdominal surgeries
TLDR
The incidence of SSIs after clean-contaminated upper abdominal surgeries was lower with the use of chlorhexidine skin preparation than with povidone iodine preparation, although the results were not statistically significant.
A comparison of chlorhexidine-alcohol versus povidone-iodine for eliminating skin flora before genitourinary prosthetic surgery: a randomized controlled trial.
A retrospective analysis of surgical site infections after chlorhexidine-alcohol versus iodine-alcohol for pre-operative antisepsis.
TLDR
No difference in the rate of SSI was found after an instantaneous protocol change from iodine-alcohol to chlorhexidine-alcohol for pre-operative topical antisepsis for preventing SSI in this single-center study conducted over a course of one year.
Preoperative Antisepsis with Chlorhexidine Versus Povidone-Iodine for the Prevention of Surgical Site Infection: a Systematic Review and Meta-analysis
TLDR
Chlorhexidine was superior to povidone-iodine in preventing postoperative SSI, especially for the clean-contaminated surgery, however, there was no statistically significant difference in the incidence of skin adverse events between CH and PI groups.
Chlorhexidine and alcohol versus povidone-iodine for antisepsis in gynecological surgery.
TLDR
Antisepsis with chlorhexidine and alcohol was associated with a significant reduction in the rate of SSIs compared to povidone-iodine antisepsis in patients undergoing elective gynecological laparotomies.
Efficacy of Chlorhexidine Alcohol over Aqueous Povidone Iodine in Prevention of Surgical Site Infection
TLDR
Ways to use chlorhexidine alcohol as an effective antiseptic for prevention of surgical site infections are recommended.
Preoperative skin antisepsis with chlorhexidine gluconate versus povidone-iodine: a prospective analysis of 6959 consecutive spinal surgery patients.
TLDR
The choice of either ChloraPrep or Betadine for preoperative skin antisepsis in spinal surgery had no significant impact on the incidence of postoperative SSI.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 39 REFERENCES
A randomized trial that compared povidone iodine and chlorhexidine as antiseptics for vaginal hysterectomy.
Chlorhexidine Provides Superior Skin Decontamination in Foot and Ankle Surgery: A Prospective Randomized Study
TLDR
Data indicate that chlorhexidine and alcohol provide better reduction in bacterial carriage than povidone-iodine, which is recommended as the surgical preparatory agent for the foot and ankle.
Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis.
Prevention of postoperative infections by administration of antimicrobial agents immediately before surgery for patients with gastrointestinal cancers.
TLDR
Preoperative AMP was useful to suppress postoperative superficial or deep incisional SSI, but was unlikely to suppress organ/space SSI or remote site infections.
Ertapenem versus cefotetan prophylaxis in elective colorectal surgery.
TLDR
Ertapenem is more effective than cefotetan in the prevention of surgical-site infection in patients undergoing elective colorectal surgery but may be associated with an increase in C. difficile infection.
Supplemental perioperative oxygen to reduce the incidence of surgical-wound infection.
TLDR
The perioperative administration of supplemental oxygen is a practical method of reducing the incidence of surgical-wound infections.
Randomized prospective comparison of fosfomycin and cefotiam for prevention of postoperative infection following urological surgery
TLDR
Data show that CTM and FOM are similarly effective in preventing infection following a wide range of urologic surgeries.
Efficacy of surgical preparation solutions in foot and ankle surgery.
TLDR
Of the three solutions tested in the present study, the combination of chlorhexidine and alcohol (ChloraPrep) was most effective for eliminating bacteria from the forefoot prior to surgery.
Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. Study of Wound Infection and Temperature Group.
TLDR
Maintaining normothermia intraoperatively is likely to decrease the incidence of infectious complications in patients undergoing colorectal resection and to shorten their hospitalizations.
Preoperative hair removal to reduce surgical site infection.
TLDR
This review found no statistically significant effect on SSI rates of hair removal and insufficient numbers of people have been involved in this research to allow confidence in a conclusion.
...
1
2
3
4
...