Chlordiazepoxide alters intravenous cocaine self-administration in rats

@article{Goeders1989ChlordiazepoxideAI,
  title={Chlordiazepoxide alters intravenous cocaine self-administration in rats},
  author={Nick E. Goeders and Marcia A. McNulty and S. Mirkis and Kevin H Mcallister},
  journal={Pharmacology Biochemistry and Behavior},
  year={1989},
  volume={33},
  pages={859-866}
}
This investigation was designed to examine the effects of benzodiazepines on intravenous cocaine self-administration in rats. Pretreatment with low doses of the benzodiazepine receptor agonist, chlordiazepoxide (0.3 to 1.0 mg/kg, IP), resulted in small but nonsignificant increases in drug intake with 0.5 mg/kg cocaine, while higher doses (10 mg/kg, IP) significantly decreased drug intake in all rats tested. The effects of chlordiazepoxide on self-administration were attenuated when the… CONTINUE READING

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